In light of an upcoming new era of human expansion in the universe, such as future space travel to Mars, the microbiome of the closed space environment needs to be examined thoroughly to identify the types of microorganisms that can accumulate in this unique environment, how long they persist and survive and their impact on human health and spacecraft infrastructure.
The development and expansion of the core facility concept are less than four decades old. The factors that favored the use of shared instrumentation facilities and the requirement for expert staff are covered by one scientist who lived during that era and represent his recollections.
Technology Showcase - Bionano Genomics: Strengthening the Core with Bionano Genome Mapping – An Easily Integrated, Cost-Effective Tool to Super-Charge Genome Assembly and Fully Reveal Whole-Genome Structural Variants in Human Genetics and Cancer Research
(208) Neuroprotective roles of fractalkine in multiple sclerosis: Characterization of novel humanized animal model
Multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS is the leading cause of nontraumatic neurological disability in young adults. Immune mediated destruction of the myelin and oligodendrocytes are considered the primary pathology of MS, but progressive axonal loss is the major cause of neurological disability.
Hydrogen-deuterium exchange (HDX) mass spectrometry and imaging mass spectrometry (IMS) are two cutting edge mass spectrometry techniques that are not frequently found in Core facilities. HDX-MS provides protein structure information and information on protein-protein interaction sites. IMS provides analyte (lipid, metabolites, drugs, and proteins) localization within tissue samples.