NIBIB's Section on High Resolution Optical Imaging
Hari Shroff, PhD
National Institute of Biomedical Imaging and Bioengineering
Dr. Hari Shroff received a B.S.E. in bioengineering from the University of Washington in 2001, and under the supervision of Dr. Jan Liphardt, completed his Ph.D. in biophysics at the University of California at Berkeley in 2006 . He spent the next three years performing postdoctoral research under the mentorship of Eric Betzig at the Howard Hughes Medical Institute's Janelia Farm Research Campus where his research focused on development of photactivated localization microscopy (PALM), an optical superresolution technique. Dr. Shroff is now chief of NIBIB's Section on High Resolution Optical Imaging laboratory, where he and his staff are developing super-resolution and light-sheet microscopes for use in biomedical research. Additional current interests include the study of neurodevelopment in simple model organisms.
Chemical Proteomics reveals the Target Space of Hundreds of Clinical Kinase Inhibitors
Prof. Dr. Bernhard Küster
Chair, Proteomics and Bioanalytics
Technische Universität München School of Life Sciences
Professor Küster (b. 1967) conducts research in the field of chemical and functional proteomics. This research focuses on a range of questions relating to how proteins interact with each other and with active pharmaceutical ingredients, which molecular mechanisms play a role in cancer and how these can be used for individual approaches to clinical treatment. He uses chemical and biochemical methods as well as spectroscopic and bioinformatic high throughput technologies. After studying chemistry at the University of Cologne, Professor Küster obtained his doctorate in biochemistry at the University of Oxford. He subsequently worked as a postdoctoral researcher in Heidelberg, Germany, and Odense, Denmark. Prior to becoming a full professor at TUM and until 2007 he was Vice President of Cellzome AG, a Heidelberg-based biotech company. Professor Küster is the Chair of the TUM Department of Biosciences and a member of the Graduate School Experimental Medicine. His research is funded by the Center for integrated Protein Science Munich (CiPSM), the German Consortium for Translational Cancer Research (DKTK) and the pharmaceutical industry. Professor Küster is one of the founders of the biotech company OmicScouts GmbH.
Barbara Wold, PhD
Bren Professor of molecular biology and Director of the Beckman Institute at the California Institute of Technology
Dr. Wold is the Bren Professor of molecular biology and Director of the Beckman Institute at Caltech. She began working on genome structure and gene regulation during embryo development for her Ph.D. thesis at Caltech, and developed ways to assay cis-regulatory element function during postdoctoral work at Columbia. She established joined the biology faculty at Caltech in 1981 where she and her colleagues have focused on learning the architecture and logic of gene networks that drive cell state transitions. They study skeletal muscle development, degeneration and regeneration as a favored model system. Recent work emphasizes new ways to quantitatively map the inputs and outputs of gene networks in a genome-wide manner using “next generation” ultra-high throughput DNA sequencing, and applying these methods to muscle and brain networks.